Class 1: Sodium Channel Blockers – Antiarrhythmic Drugs
ثبت نشده
چکیده
منابع مشابه
Use of amiodarone to prevent atrial fibrillation after cardiac surgery.
Laura Brantman is an acute care nurse practitioner at the University of California, San Francisco. Jill Howie is an associate clinical professor at the University of California, San Francisco and a nurse practitioner at Kaiser Permanente. including digoxin, β-adrenergic blockers, calcium channel blockers, and class I and class III antiarrhythmic agents, to prevent postoperative atrial fibrillat...
متن کاملRole of K+ channel activators in cardiac electrophysiology and arrhythmias.
T he search for new antiarrhythmic agents has long centered around drugs capable of inhibiting one or more of the ionic currents responsible for transmembrane activity in cardiac tissues and drugs capable of interfering with the influence of the autonomic nervous system on the heart. As a consequence, we are today equipped with an armamentarium of sodium, calcium, and potassium channel blockers...
متن کاملPITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers
BACKGROUND Antiarrhythmic drugs are widely used to treat patients with atrial fibrillation (AF), but the mechanisms conveying their variable effectiveness are not known. Recent data suggested that paired like homeodomain-2 transcription factor (PITX2) might play an important role in regulating gene expression and electrical function of the adult left atrium (LA). OBJECTIVES After determining ...
متن کاملInhibition of Cardiac Ca Release Channels (RyR2) Determines Efficacy of Class I Antiarrhythmic Drugs in Catecholaminergic Polymorphic Ventricular Tachycardia
Background—Catecholaminergic polymorphic ventricular tachycardia (CPVT) is caused by mutations in the cardiac ryanodine receptor (RyR2) or calsequestrin (Casq2) and can be difficult to treat. The class Ic antiarrhythmic drug flecainide blocks RyR2 channels and prevents CPVT in mice and humans. It is not known whether other class I antiarrhythmic drugs also block RyR2 channels and to what extent...
متن کاملMechanism of antiarrhythmic effects of flecainide in catecholaminergic polymorphic ventricular tachycardia.
Mechanism of Antiarrhythmic Effects of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia To the Editor: We read with interest the recent article by Liu et al, in Circulation Research, on the mechanism underlying the antiarrhythmic effects of flecainide in catecholaminergic polymorphic ventricular tachycardia (CPVT).1 They conclude that Na channel block but not inhibition of th...
متن کامل